B-K mole syndrome. Cutaneous and ocular malignant melanoma
D. H. Abramson, R. S. Rodriguez-Sains and R. Rubman
A 51-year-old white man had the B-K mole syndrome (multiple large atypical
cutaneous nevi of the upper part of the trunk and extremities, inherited as
an autosomal dominant trait, and thought to be more susceptible to
malignant transformation), so named after two patients in whom the syndrome
was first observed. Two cutaneous malignant melanomas (thigh and back) and
an ocular malignant melanoma (ciliary body and iris) simultaneously
developed. Patients with B-K mole syndrome have been known to have a very
high risk for the development of cutaneous melanoma (including multiple
primary cutaneous melanomas) and multiple primary malignancies. There may
be a propensity in these patients for development of ocular melanomas.
