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Ocular Microbial Flora in Immunodeficient Patients
Mitchell H. Friedlaender, MD;
Robert J. Masi, MD;
Masao Osumoto, MA;
Gilbert Smolin, MD;
Arthur J. Ammann, MD
Arch Ophthalmol. 1980;98(7):1211-1213.
Abstract
• The eyes of 20 patients with primary immunodeficiency syndromes were examined, and microbial cultures of their lids and conjunctivae were made. Nine patients had a history of recurrent external ocular infections, and six of these had active blepharitis or blepharoconjunctivitis at the time of examination. A single pathogenic bacterium was isolated from the lids and conjunctivae of six patients with a history of infection; a mixture of two possible pathogens was cultured from eyes of three other patients. Three of the nine patients with infections had impaired B-cell and intact T-cell immunity, whereas three patients had impaired B-cell and T-cell immunity. Two patients had chronic granulomatous disease in which a defect in phagocytosis was the predominant immunologic abnormality, and one patient (with mucocutaneous candidiasis) had intact B- and T-cell function at the time of testing. Although the immunodeficient patients had a higher incidence of lid or conjunctival infection than 20 age-matched controls, the microbial flora of the lids and conjunctivae did not differ between the two groups.
Author Affiliations
From the Francis I. Proctor Foundation for Research in Ophthalmology (Drs Friedlaender, Masi, and Smolin and Mr Okumoto) and the Department of Pediatrics, Immunology Service (Dr Ammann), University of California, San Francisco.
Footnotes
Accepted for publication Nov 12, 1979.
Reprint requests to Francis I. Proctor Foundation, University of California, San Francisco, CA 94143 (Dr Friedlaender).
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