Immunofluorescent studies of the eye in Waldenstrom's macroglobulinemia

A. H. Freidman, A. Marchevsky, J. G. Odel, M. A. Gerber and S. N. Thung

The eyes of a 53-year-old woman with K light chain macroglobulinemia were studied histopathologically. Retinal hemorrhages were observed on gross examination. Microscopic examination disclosed eosinophilic, PAS-positive deposits in cystoid spaces within the outer plexiform layer, in the inner retina, and about photoreceptors. Immunofluorescent studies showed that the deposits contained IgM. Aneurysmal dilations of small retina vessels were demonstrated as well.