Cefaclor levels in human aqueous humor
J. L. Axelrod and R. S. Kochman
In an attempt to investigate penetration of cefaclor into human aqueous
humor, we administered 500-mg and 1-g doses of cefaclor to 39 patients
about to undergo cataract extraction. Average aqueous humor levels of 0.27,
0.27, and 0.17 microgram/mL were achieved at 1, 2, and 4 hours,
respectively, after the 500-mg oral dose. After 1 g orally, we found
average aqueous humor levels of 0.61, 0.64, 0.72, 0.4, and 0.31
microgram/mL at 1, 2, 3, 4, and 5 hours, respectively. Therapeutic levels
in primary aqueous humor were consistently achieved against Streptococcus
pneumoniae and St pyogenes, group A.
