Reclassification of intraocular reticulum cell sarcoma (histiocytic lymphoma). Immunologic characterization of vitreous cells
H. J. Kaplan, T. A. Meredith, T. M. Aaberg and R. H. Keller
Systemic and orbital reticulum cell sarcomas (RCSs) have been shown to be
derived from lymphocytes, not reticulum cells or histiocytes, by
immunologic and cytochemical characterization. Unfortunately, until now it
has not been technically possible to study intraocular RCS. We have been
able to immunologically characterize a primary intraocular RCS in a patient
with chronic lymphocytic leukemia (ie, Richter's syndrome), establishing
its origin from B lymphocytes. A review of the clinical course of such
tumors indicates that primary intraocular non-Hodgkin's lymphoma is usually
a manifestation of a systemic neoplasm of the immune system.
