This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (42)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Clinical Study of Ocular Interactions

Ivan Goldberg, MB, BS, FRACS; Frank S. Ashburn, Jr, MD; Paul F. Palmberg, MD, PhD; Michael A. Kass, MD; Bernard Becker, MD

Arch Ophthalmol. 1980;98(3):484-486.

Abstract
• In a crossover design study, we assessed effects on intraocular pressure, pupillary diameter, pulse rate, and blood pressure over six hours of one drop of 0.5% timolol maleate and 2% epinephrine hydrochloride in one eye. Both eyes of each patient had been pretreated for one week with twice-daily applications of epinephrine or timolol, respectively. In random sequence, 20 patients (40 eyes) participated in both phases of the study. Pretreatment with timolol significantly reduced the ocular hypotensive effect of epinephrine (from 15.3% to 4.6%); epinephrine pretreatment did not affect the pressure reduction of timolol. Pretreatment with timolol enhanced the mydriatic effect of epinephrine (from 35.8% to 71.9% pupillary dilation); pretreatment with epinephrine resulted in an apparent mydriatic effect for timolol.

Author Affiliations
From the Glaucoma Center, Department of Ophthalmology, Washington University School of Medicine, St Louis.

Footnotes
Accepted for publication July 16, 1979.

Reprint requests to Glaucoma Center, Department of Ophthalmology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110 (Dr Kass).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The Efficacy of Apraclonidine as an Adjunct to Timolol Therapy
Stewart et al.
Arch Ophthalmol 1995;113:287-292.
ABSTRACT  

Randomized Clinical Trials on Medical Treatment of Glaucoma: Are They Appropriate to Guide Clinical Practice?
Rossetti et al.
Arch Ophthalmol 1993;111:96-103.
ABSTRACT  

A Combination of Levobunolol and Dipivefrin for the Treatment of Glaucoma
Allen et al.
Arch Ophthalmol 1988;106:904-907.
ABSTRACT  

Additive Effect of Betaxolol and Epinephrine in Primary Open Angle Glaucoma
Allen and Epstein
Arch Ophthalmol 1986;104:1178-1184.
ABSTRACT  

Timolol and Epinephrine: Long-term Evaluation of Concurrent Administration
Korey et al.
Arch Ophthalmol 1982;100:742-745.
ABSTRACT  

Additive Effect of Epinephrine to Timolol Therapy in Primary Open Angle Glaucoma
Cyrlin et al.
Arch Ophthalmol 1982;100:414-418.
ABSTRACT  

Fluorophotometric Study of Epinephrine and Timolol in Human Subjects
Schenker et al.
Arch Ophthalmol 1981;99:1212-1216.
ABSTRACT