Supersensitivity to topical epinephrine after long-term epinephrine therapy

A. J. Flach and S. G. Kramer

Two patients received long-term topical therapy with epinephrine in one eye. One week after cessation of therapy, the treated eye in each patient showed more sensitivity to epinephrine than the untreated eye. The possibility of denervation supersensitivity and some clinical implications of this observation are discussed.