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II. Effect on Gentamicin-Resistant Pseudomonas Keratitis

Gilbert Smolin, MD; Masao Okumoto, MA; Lin Leong-Sit, MD

Arch Ophthalmol. 1980;98(3):473-474.

Abstract
• In an experimental model of Pseudomonas keratitis produced by a gentamicin sulfate-resistant, tobramycin sulfate-sensitive strain of P aeruginosa, the results of two treatment regimens—(1) with gentamicin and tobramycin alone and (2) with gentamicin, tobramycin, and a steroid—were evaluated. All of the animals exhibited ultimately the same amount of corneal inflammation and corneal scarring. In the group receiving the antibioticsteroid combination, the corneal lesions healed more slowly.

Author Affiliations
From the Francis I. Proctor Foundation for Research in Ophthalmology and Department of Ophthalmology, University of California San Francisco.

Footnotes
Accepted for publication July 13, 1979.

Reprint requests to Francis I. Proctor Foundation, University of California San Francisco, San Francisco, CA 94143 (Dr Smolin).

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