Commonly used intraocular medications and the corneal endothelium
R. J. Olson, H. Kolodner, P. Riddle and H. Escapini Jr
Forty-one cats had balanced salt solution, chymotrypsin, epinephrine
hydrochloride with preservatives in varying concentrations, acetylcholine
chloride, and carbachol injected intracamerally to determine the toxic
effects on the endothelium. Specular microscopy was performed both before
and after injection, and for each of the medications, the cell densities
were compared with the results obtained with the balanced salt solution.
The mean postinjection density as compared with the preinjection density
for the medications varied between 98% and 108%, and there were no
statistically significant differences between each medication group and the
balanced salt solution results. From the results of this study, it is
believed that when indicated, these medications probably do not produce
substantial toxic effects on the corneal endothelium.