This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Joel S. Mindel, MD, PhD; S. T. Shaikewitz; Steven M. Podos, MD

Arch Ophthalmol. 1980;98(12):2220-2223.

Abstract
• Phenylephrine pivalate has been assumed to be a prodrug devoid of important intrinsic activity because of its structural similarity to dipivefrin (dipivalyl epinephrine). However, unlike dipivefrin, the pharmacologic activity of phenylephrine pivalate was not prevented by prior administration of echothiophate iodide. Rabbits pretreated bilaterally with 0.25% echothiophate for two and seven days had similar mydriasis, both in quantity and duration, after receiving 10% phenylephrine hydrochloride to one eye and 1% phenylephrine pivalate to the other eye. This was consistent with the hypothesis that the phenylephrine pivalate molecule has important -adrenergic activity regardless of whether it is converted to phenylephrine.

Author Affiliations
From the Ophthalmology Section, Bronx Veterans Administration Hospital, New York, and the Departments of Ophthalmology (Drs Mindel and Podos and Mr Shaikewitz) and Pharmacology (Dr Mindel), Mount Sinai School of Medicne, New York.

Footnotes
Accepted for publication April 28, 1980.

Reprint requests to Department of Ophthalmology, Annenberg Bldg 22-14, 1 Gustave Levy PI, New York, NY 10029 (Dr Mindel).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?