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Once a Day vs Twice a Day

David B. Soll, MD

Arch Ophthalmol. 1980;98(12):2178-2181.

Abstract
• Regimens of once-a-day or twice-aday 0.25% timolol ophthalmic solution were compared for efficacy and tolerability in a four-week study of 41 patients with chronic open-angle glaucoma and elevated, untreated intraocular pressure. Significant reductions in IOP relative to untreated baseline values were achieved within a range of 18% to 25%. No significant between-group differences were noted, although the twice-a-day group had somewhat lower IOPs at each evaluation point and the once-a-day group had somewhat fewer subjective symptoms of local irritation. A statistically significant decrease from baseline in mean pulse rate was noted in the twice-a-day treatment group after two weeks; no clinically significant or serious adverse reactions occurred in any patient. Both once-daily and twice-daily administrations of 0.25% timolol ophthalmic solution were found to be effective and well tolerated in the population studied.

Author Affiliations
From the Department of Ophthalmology, Hahnemann Medical College and Hospital, Philadelphia.

Footnotes
Accepted for publication April 8, 1980.

Reprint requests to 5001 Frankford Ave, Philadelphia, PA 19124 (Dr Soll).

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