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Mark O. M. Tso, MD; Jose G. Cunha-Vaz, MD, PhD; Chi-Yen Shih, MS; Carl W. Jones

Arch Ophthalmol. 1980;98(11):2032-2040.

Abstract
• Rats with experimental diabetes (induced by streptozocin [Streptozotocin]) were studied by vitreous fluorophotometry and horseradish peroxidase tracer technique. Vitreous fluorescein sodium concentration notably increased four to eight days after a single dose of streptozocin. No leakage from the retinal vasculature could be demonstrated by the horseradish peroxidase tracer study, but three types of retinal pigment epithelial (RPE) lesions were observed. The RPE lesions seemed to be partially responsible for the increase of vitreous fluorescein concentration.

Author Affiliations
From the Georgiana Theobald Ophthalmic Pathology Laboratory, Department of Ophthalmology, University of Illinois Eye and Ear Infirmary (Drs Tso and Cunha-Vaz and Ms Shih); and the Department of Anatomy, Abraham Lincoln School of Medicine (Mr Jones), Chicago.

Footnotes
Accepted for publication Feb 14, 1980.

Reprint requests to Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, 1855 W Taylor St, Chicago, IL 60612 (Dr Tso).

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