Clinicopathologic Study of Blood-Retinal Barrier in Experimental Diabetes Mellitus

doi:10.1001/archopht.1980.01020040884020

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Vol. 98 No. 11, November 1980

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Clinicopathologic Study of Blood-Retinal Barrier in Experimental Diabetes Mellitus

Mark O. M. Tso, MD; Jose G. Cunha-Vaz, MD, PhD; Chi-Yen Shih, MS; Carl W. Jones

Arch Ophthalmol. 1980;98(11):2032-2040.

Abstract

• Rats with experimental diabetes (induced by streptozocin[Streptozotocin]) were studied by vitreous fluorophotometryand horseradish peroxidase tracer technique. Vitreous fluoresceinsodium concentration notably increased four to eight days aftera single dose of streptozocin. No leakage from the retinal vasculaturecould be demonstrated by the horseradish peroxidase tracer study,but three types of retinal pigment epithelial (RPE) lesionswere observed. The RPE lesions seemed to be partially responsiblefor the increase of vitreous fluorescein concentration.

Author Affiliations

From the Georgiana Theobald Ophthalmic Pathology Laboratory, Department of Ophthalmology, University of Illinois Eye and Ear Infirmary (Drs Tso and Cunha-Vaz and Ms Shih); and the Department of Anatomy, Abraham Lincoln School of Medicine (Mr Jones), Chicago.

Footnotes

Accepted for publication Feb 14, 1980.

Reprint requests to Department of Ophthalmology, Universityof Illinois Eye and Ear Infirmary, 1855 W Taylor St, Chicago,IL 60612 (Dr Tso).

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