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Unusual Superficial Stromal Corneal Deposits in IgG Monoclonal Gammopathy

Richard A. Eiferman, MD; Merlyn M. Rodrigues, MD, PhD

Arch Ophthalmol. 1980;98(1):78-81.

Abstract
• Unusual corneal stromal deposits at the level of Bowman's membrane and superficial stroma were associated with severe photophobia and tearing as the initial signs of an IgG monoclonal gammopathy. A corneal biopsy specimen showed superficial stroma areas that stained red with Masson trichrome stain. These deposits were positive for IgG and chains. Histopathologic examination revealed focal disruption in Bowman's membrane with extension into the epithelium. Electron microscopy of the deposits disclosed parallel linear profiles compatible with immunoglobulin.

Author Affiliations
From the Department of Ophthalmology, University of Louisville, and the Veterans Administration Medical Center, Louisville (Dr Eiferman), and the National Eye Institute, Bethesda, Md (Dr Rodrigues).

Footnotes
Accepted for publication April 9, 1979.

Reprint requests to University of Louisville, 301 E Walnut St, Louisville, KY 40202 (Dr Eiferman).

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