Vitreous inhibition of tumor neovascularization
S. M. Felton, G. C. Brown, N. T. Felberg and J. L. Federman
Cartilage has been reported to contain a factor that inhibits tumor
neovascularization. Rabbit vitreous, another avascular tissue, has also
been shown recently to have an inhibitory effect on tumor
neovascularization. This report describes our results on the effects of
bovine and human vitreous on tumor neovascularization with use of a rabbit
cornea model. Inhibition of neovascularization was observed with both
bovine and human vitreous in the form of reduced new blood vessel growth
over and around the vitreous pellet and subsequent delayed exophytic tumor
growth. Stimulation of neovascularization by bovine and human vitreous was
also observed as an early, short-lived response.
