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Ocular Effects in Normal Rabbits of Topically Applied LabetalolA Combined  - and β-Adrenergic Antagonist
David L. Murray;
Steven M. Podos, MD;
Chau-po Wei, MD, PhD;
Irving H. Leopold, MD, DSc
Arch Ophthalmol. 1979;97(4):723-726.
Abstract
• The ocular effects in rabbits of topically applied labetalol hydrochloride, a new  - and β-adrenergic receptor blocking agent, were studied. A dose-related reduction in intraocular pressure (IOP) followed treatment with 0.01% to 1% solutions. Labetalol at a 1% concentration had no effect on pupil diameter. The same dose blocked an increase in IOP after water loading but did not significantly alter the coefficient of aqueous outflow facility. Mydriasis induced by phenylephrine hydrochloride was competitively inhibited.
Author Affiliations
From the Departments of Ophthalmology, California College of Medicine, University of California, Irvine (Drs Leopold and Wei and Mr Murray), and Mount Sinai School of Medicine, City University of New York (Dr Podos).
Footnotes
Accepted for publication July 3, 1978.
Presented in part before the Annual Alumni Meeting at the University of Chicago, May 1977.
Reprint requests to Department of Ophthalmology, California College of Medicine, University of California, Irvine, CA 92717 (Dr Leopold).
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