Combined amphotericin B and rifampin treatment of experimental Candida albicans keratitis
G. A. Stern, M. Okumoto and G. Smolin
In a model of experimental Candida albicans keratitis in rabbits, treatment
with a combination of amphotericin B and rifampin was compared with
treatment with amphotericin B alone. Both modes of therapy substantially
reduced the number of organisms in the cornea below the number in untreated
control corneas. In the group treated with combined therapy, there were
significantly fewer organisms in the cornea after three days of therapy
than in the group treated with amphotericin B alone. The results of this
study indicate that the treatment of C albicans keratitis in rabbits with
combined amphotericin B and rifampin is more effective than treatment with
amphotericin B alone.
