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Tumor-Associated Antibodies in the Serum of Patients With Ocular MelanomaIII. Immunoperoxidase Detection
Norman T. Felberg, PhD;
J. Miguel Pro-Landazuri, MD;
Jerry A. Shields, MD;
Jay L. Federman, MD
Arch Ophthalmol. 1979;97(2):256-259.
Abstract
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• The indirect immunofluorescent and indirect immunoperoxidase methods to detect tumor-associated antibodies (TAAs) in the plasma of patients with ocular melanomas were examined with commercially available conjugates. Testing indicated comparable titers and staining between the two techniques using snap-frozen uveal melanoma cells.
With the indirect immunoperoxidase method it was found that 78% (57) of 73 patients with uveal melanoma had TAAs, while 24% (25) of 106 control subjects were positive for TAAs (P < .001). Seventy-eight percent (11) of 14 patients with metastases to the choroid also had TAAs using snap-frozen cells from choroidal melanoma tumors, which indicates that it was not possible to distinguish this group of patients from those patients with primary uveal melanoma.
Tumor-associated antibodies have not been correlated to various prognostic indicators, but serial testing after therapy may show the biologic meaning of such antibodies in patients with ocular melanoma.
Author Affiliations
From the Retina Research Laboratory (Drs Federman and Pro-Landazuri), the Oncology Unit of the Retina Service (Dr Shields), and the Research Institute (Dr Felberg), Wills Eye Hospital, Philadelphia.
Footnotes
Accepted for publication May 1, 1978.
Reprint requests to Retina Research Laboratory, Wills Eye Hospital, 1601 Spring Garden St, Philadelphia, PA 19130 (Dr Federman).
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