Intraocular Penetration of Subconjunctivally Administered 14C-Fluorouracil in Rabbits

doi:10.1001/archopht.1979.01020020591019

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Vol. 97 No. 12, December 1979

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Intraocular Penetration of Subconjunctivally Administered 14C-Fluorouracil in Rabbits

Jack Rootman, MD; John Tisdall, MD; Gedy Gudauskas, PharmD; Aleck Ostry

Arch Ophthalmol. 1979;97(12):2375-2378.

Abstract

• Fluorouracil is given for a variety of neoplasms by variousadministrative routes. Toxicity of susceptible normal tissuelimits systemic dosage, but at this level intraocular tissuemay not receive tumor-inhibiting concentrations. Subconjunctivaladministration of 6.25 mg of ¹⁴C-fluorouracil in 0.5-mL dosagesresulted in a peak anterior chamber concentration of 69.5 µg/mLand a peak vitreous concentration of 10.5 µg/mL over the12 hours tested. This resulted in no visible ocular damage.The intraocular levels achieved were greater than the concentrationreported to inhibit selected tumors. The total dosage administeredwas considerably below the level of systemic toxicity.

Author Affiliations

From the Departments of Ophthalmology (Drs Rootman and Tisdall and Mr Ostry) and Pathology (Dr Rootman), University of British Columbia; Vancouver General Hospital (Dr Rootman); and Advanced Therapeutics Department, Cancer Control Agency of British Columbia, Vancouver (Dr Gudauskas).

Footnotes

Accepted for publication March 7, 1979.

Read before the Association for Research in Vision and Ophthalmology,Western Section, Seattle, September 1978.

Reprint requests to Department of Ophthalmology, 2550 WillowSt, Vancouver, British Columbia V5Z 3N9 (Dr Rootman).

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