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Aspirin, Cyclophosphamide, and Dexamethasone Effects on Experimental Secondary Herpes Simplex Uveitis
Richard F. Dennis, MD;
Jang O. Oh, MD, PhD
Arch Ophthalmol. 1979;97(11):2170-2174.
Abstract
• The effects of aspirin, cyclophosphamide, and dexamethasone on secondary herpes simplex uveitis were studied in rabbits. Neither daily treatment with aspirin (rectal suppositories, 650 mg begun 24 hours before challenge) nor cyclophosphamide injections every two days (80 mg begun eight days before challenge) had any effect on the severity of the uveitis, on the rise in intraocular pressure (IOP), or on the host's immune responses. As in the control animals, infectious herpes simplex virus (HSV) could not be isolated from iris tissues of either aspirin- or cyclophosphamide-treated rabbits. On the other hand, twice-daily treatment with topical dexamethasone (0.1% drops begun 24 hours before challenge) lessened the severity of the uveitis appreciably and suppressed the rise in IOP, but iris tissues yielded infectious HSV in two of ten eyes. Although the dexamethasone had no effect on the neutralizing-antibody or macrophage migration inhibition factor, it markedly suppressed the chemotactic activity of the aqueous humor for both polymorphonuclear leukocytes and macrophages.
Author Affiliations
From the Francis I. Proctor Foundation, University of California, San Francisco.
Footnotes
Accepted for publication Feb 22, 1979.
Read in part before the annual meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Fla, April 27, 1977.
Reprint requests to Francis I. Proctor Foundation, S-315, University of California, San Francisco, CA 94143 (Dr Oh).
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