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Clinical Investigation With the Specular Microscope

Ronald A. Laing, PhD; Marita M. Sandstrom; Howard M. Leibowitz, MD; Amado R. Berrospi, MD

Arch Ophthalmol. 1979;97(10):1870-1874.

Abstract
• Four patients, each of whom had had an uncomplicated cataract extraction, were examined because of an apparent epithelialization of the anterior chamber. In each instance, the diagnosis was later verified histopathologically. The involved eye was photographed with the clinical specular microscope and the endothelial photomicrographs were analyzed. It was noted that considerable endothelial cell loss had occurred, as evidenced by the large size of the remaining cells. Endothelial cells were present but they were grossly abnormal well below the demarcation line visible with the slit-lamp biomicroscope. These in vivo observations support the thesis that damage to the corneal endothelium is a necessary factor for epithelial invasion of the anterior chamber.

Author Affiliations
From the Department of Ophthalmology, Boston University School of Medicine and the Massachusetts Lions Eye Research Laboratory, Boston.

Footnotes
Accepted for publication March 12, 1979.

Reprint requests to Boston University School of Medicine, 80 E Concord St, Boston, MA 02118 (Dr Laing).

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