This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Edward L. Howes, Jr, MD; Virginia K. Cruse

Arch Ophthalmol. 1978;96(9):1668-1676.

Abstract
• An immunogenic uveitis was produced in rabbits by the intravitreal injection of bovine -globulin. Four to six months later, an alteration in vascular permeability was determined by greater accumulation of iodinated l 125 serum albumin in the previously inflamed eye than in the normal eye. An altered vascular permeability was found only in eyes with profound structural changes. Possible sites of extravascular protein leakage were: (1) proliferated blood vessels in the posterior chamber and vitreous; and (2) leakage through the disrupted and scarred ciliary epithelium. In eyes without evidence of altered vascular permeability, a persistent chronic inflammation was observed, and gliosis and chorioretinal scarring was prominent.

Author Affiliations
From the Department of Pathology, University of California and San Francisco General Hospital.

Footnotes
Accepted for publication Feb 6, 1978.

Reprint requests to Department of Pathology, University of California, San Francisco General Hospital, San Francisco, CA 94110 (Dr Howes).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?