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Alternate Pathway Activation of Complement in a Proteus mirabilis Ulceration of the Cornea
Bartly J. Mondino, MD;
Stuart I. Brown, MD;
Bruce S. Rabin, MD, PhD;
Jorge Bruno, MD
Arch Ophthalmol. 1978;96(9):1659-1661.
Abstract
• A 63-year-old patient had an extensive infiltration, ulceration, and eventual perforation of the cornea caused by Proteus mirabilis. Histopathological examination of corneal tissue that was obtained at keratoplasty disclosed that the stroma was ulcerated with a diffuse infiltration of polymorphonuclear leukocytes. Immunopathological examination of the cornea revealed prominent and diffuse staining for properdin and C3 complement. There was an absence of staining for IgG, IgA, IgM, IgE, and C4 complement. These findings suggest that the alternate pathway of complement was activated in this ulcerated cornea and that immunopathological phenomena contribute to the polymorphonuclear infiltration found with Gram-negative ulcerations of the human cornea.
Author Affiliations
From the Department of Ophthalmology, University of Pittsburgh School of Medicine and Eye & Ear Hospital (Drs Mondino, Brown, and Bruno), and the Division of Clinical Immunopathology, Department of Pathology, University of Pittsburgh School of Medicine (Dr Rabin).
Footnotes
Accepted for publication Dec 8, 1977.
Reprint requests to Department of Ophthalmology, Eye & Ear Hospital, 230 Lothrop St, Pittsburgh, PA 15213 (Dr Brown).
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