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G. B. Arden, MB; A. G. Gucukoglu, MD

Arch Ophthalmol. 1978;96(9):1626-1629.

Abstract
• A retrospective study of 57 patients with retrobulbar neuritis (RBN) was carried out with a new test of contrast sensitivity that utilizes printed sinusoidal gratings. For 21 patients suffering from multiple sclerosis, visual abnormality was detected in 18 "affected" eyes and 12 apparently unaffected eyes. For the 36 patients with RBN, abnormalities were detected in 29. In seven of these cases, the grating test showed bilateral impairment. The grating test seemed to be a more sensitive indicator of demyelinization than other psychophysical tests. In 24 of the patients with the least severe disease, the grating test was compared with the visual evoked response. The probability of making a positive diagnosis was.54 for the evoked potential alone, and.71 for the grating test alone.

Author Affiliations
From the Electrodiagnostic Clinic, Moorfields Eye Hospital, London. Dr Arden is now with the Department of Ophthalmology, New York University Medical Center. Dr Gucukoglu is now with the University Eye Clinic, Faculty of Medicine, Istanbul, Turkey.

Footnotes
Accepted for publication Dec 22, 1977.

Reprint requests to Department of Ophthalmology, New York University Medical Center, 550 First Ave, New York, NY 10016 (Dr Arden).

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