 |
|
Intraocular Pressure Response to Topical Epinephrine and HLA-B12
Dong H. Shin, MD, PhD;
Michael A. Kass, MD;
Bernard Becker, MD
Arch Ophthalmol. 1978;96(6):1012-1013.
Abstract
• Twenty high responders to topical corticosteroids (intraocular pressure > 31 mm Hg after six weeks of topical 0.1% dexamethasone, four times daily) and 20 low responders (IOP < 20 mm Hg) of similar age, sex, race, initial IOP, and facility of outflow were selected. After 24 hours of treatment (two doses) of topical 1% epinephrine hydrochloride, the high corticosteroid responders showed a mean (±SD) corrected decrease in IOP of 3.6 ± 2.0 mm Hg as opposed to 1.8 ± 2.1 mm Hg in the low corticosteroid responders. Within both corticosteroid groups, individuals with the antigen HLA-B12 showed significantly greater decreases in IOP. This suggested that the presence of HLA-B12 was not only associated with increased responses to corticosteroids but also to epinephrine.
Author Affiliations
From the Glaucoma Center, Washington University School of Medicine, St Louis. Dr Shin is now with the Department of Ophthalmology and the Kresge Eye Institute, Wayne State University School of Medicine, Detroit.
Footnotes
Accepted for publication Sept 6, 1977.
Reprint requests to Glaucoma Center, Department of Ophthalmology, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110 (Dr Kass).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
A Simplified Test of Epinephrine Responsiveness
Kass and Becker
Arch Ophthalmol 1978;96:999-1000.
ABSTRACT
|
