Soluble gentamicin ophthalmic inserts as a drug delivery system
S. E. Bloomfield, T. Miyata, M. W. Dunn, N. Bueser, K. H. Stenzel and A. L. Rubin
A comparison was made of soluble 14C-gentamicin ophthalmic inserts with
drop, ointment, and the subconjunctival routes of administration. The
insert is a solid, solubilizable collagen polymer containing
14C-gentamicin. We compared the levels of 14C-gentamicin in the rabbit tear
film and in multiple corneal and scleral biopsies to determine which route
of administration gave the best results. The wafer route of administration
gave the highest tear film and tissue concentration of drug. The tear film
concentration by subconjunctival injection was surprisingly low. Soluble
collagen inserts offer a new method of delivering high doses of gentamicin
in infected corneal tissue in a convenient and atraumatic fashion.
