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Effects on Intraocular Pressure and Vitreous Volume

Frank P. Killey; Henry F. Edelhauser, PhD; Thomas M. Aaberg, MD

Arch Ophthalmol. 1978;96(3):511-515.

Abstract
• Partial vitrectomies were performed on rabbits and the amount of vitreous removed was replaced with either 100% sulfur hexafluoride (SF₆), 100% octofluorocyclobutane (freon-C318), 40% SF₆, or air. Intraocular pressure and vitreous volume were determined. Replacing 40% of the initial vitreous volume with either 100% SF₆ or 100% octofluorocyclobutane caused an increase over 20 mm Hg in the IOP with an associated loss of the remaining vitreous, whereas replacement with 40% SF₆ or air caused no significant increase in IOP. Replacement with 40% SF₆ caused a significant loss of the remaining vitreous, whereas the air replacement did not result in a vitreous loss. The experiments were repeated substituting only 20% of initial vitreous volume with 100% SF₆ and 100% octofluorocyclobutane. Using this amount of SF₆ and octofluorocyclobutane, the IOP did not increase but an associated vitreous loss occurred equal to twice the amount of SF₆ injected and three times the amount of octofluorocyclobutane injected.

Author Affiliations
From the Departments of Physiology and Ophthalmology, Medical College of Wisconsin, Milwaukee.

Footnotes
Accepted for publication June 14, 1977.

Reprint requests to Department of Physiology, Medical College of Wisconsin, 561 N 15th St, Milwaukee, WI 53233 (Dr Edelhauser).

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