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Gerhard W. Cibis, MD; John T. Flynn, MD; E. Barry Davis

Arch Ophthalmol. 1978;96(2):299-302.

Abstract
• Fatal encephalitis with accompanying retinitis developed in a previously healthy 18-month-old infant. Clinically the disease appeared as whitish-yellow punctate lesions, perivascular cuffing, and hemorrhage. The antibody titer to herpes simplex rose from 1:8 on the day of admission to 1:256 on the day of death. Postmortem, intranuclear inclusion bodies that were typical of those found with herpesvirus were seen in the brain and retina. Viral particles consistent with those of herpesvirus were found by electron microscopy in the brain and in the inner-nuclear and ganglion-nerve fiber layers of the retina. This demonstrates the direct infectious nature of herpetic retinitis. Hematogenous spread of the virus to the retina is presumed.

Author Affiliations
From the Department of Ophthalmology, the Bascom Palmer Eye Institute, University of Miami (Fla) School of Medicine. Dr Cibis is now with The Children's Mercy Hospital, Kansas City, Mo.

Footnotes
Accepted for publication April 14, 1977.

Reprint requests to The Children's Mercy Hospital, 24th at Gillham Rd, Kansas City, MO 64108 (Dr Cibis).

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