Ascorbate therapy in impaired neutrophil and monocyte chemotaxis. With atopy, hyperimmunoglobulinemia E, and recurrent infection
C. S. Foster and E. J. Goetzl
A Candida albicans corneal ulcer developed in a 24-year-old man with a
history of eczema, asthma, and multiple bacterial infections since
childhood. The infection responded well to oral flucytosine (12 g/day for
15 days) and topical amphotericin B. Positive laboratory findings included
eosinophilla, hyperimmunoglobulinemia E, and impaired neutrophil and
monocyte spontaneous migration and chemotactic responses. Ascorbic acid
corrected the monocyte defect in vitro and in vivo, but had no effect on
neutrophil function.
