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With Atopy, Hyperimmunoglobulinemia E, and Recurrent Infection

C. Stephen Foster, MD; Edward J. Goetzl, MD

Arch Ophthalmol. 1978;96(11):2069-2072.

Abstract
• A Candida albicans corneal ulcer developed in a 24-year-old man with a history of eczema, asthma, and multiple bacterial infections since childhood. The infection responded well to oral flucytosine (12 g/day for 15 days) and topical amphotericin B.

Positive laboratory findings included eosinophilia, hyperimmunoglobulinemia E, and impaired neutrophil and monocyte spontaneous migration and chemotactic responses. Ascorbic acid corrected the monocyte defect in vitro and in vivo, but had no effect on neutrophil function.

Author Affiliations
From the Department of Ophthalmology, Harvard Medical School, the Cornea Service, Massachusetts Eye and Ear Infirmary, and the Department of Cornea Research, Eye Research Institute of Retina Foundation, Boston, (Dr Foster), and the Howard Hughes Medical Institute Laboratories for the Study of Immunological Diseases, the Department of Medicine, Robert Breck Brigham Hospital, and Harvard Medical School, Boston (Dr Goetzl).

Footnotes
Accepted for publication March 27, 1978.

Reprint requests to the Department of Cornea Research, Eye Research Institute of Retina Foundation, 20 Staniford St, Boston, MA 02114 (Dr Foster).

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