Trifluridine in resistant human herpetic keratitis

R. A. Hyndiuk, R. E. Charlin, T. V. Alpren and R. O. Schultz

Patients with active dendritic herpetic keratitis that was unresponsive to topical idoxuridine or vidarabine therapy were treated topically with a 1% solution of trifluridine. The dendritic ulcers healed in an average time of 6.1 days. All patients tolerated the drug well except for one patient in whom a reversible crystalline epithelial keratitis developed.