Studies of hyperthermia in optic neuropathy. Consideration of a humoral factor
P. H. Zweifach
Three patients with multiple sclerosis and prominent Uhthoff's symptom were
studied. Visual loss was found to be related not only to increase in body
temperature but to the rate of increase. Blood removed at the time of
maximal visual loss and readministered in the normothermic state did not
reproduce the symptom. The study supports the prevailing concept that
Uhthoff's symptom is a direct effect of hyperthermia on conduction in
damaged axons.
