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Herpes Simplex Virus Types 1 and 2 in Ocular Disease
Dieter Neumann-Haefelin, MD;
Rainer Sundmacher, MD;
Günter Wochnik;
Brigette Bablok
Arch Ophthalmol. 1978;96(1):64-69.
Abstract
• In a continuous series of 457 patients with presumed herpetic eye disease, virus isolation and typing revealed 154 patients with herpes simplex virus type 1 and three patients with type 2 infections. In 219 isolates that were examined for neutralization by specific antisera, for growth in human fibroblasts, and, in part, for temperature sensitivity, there were found substantial strain differences in addition to the type-specific characteristics. The clinical features of each of the three type 2 infections are described in detail. A suggestive correlation found between clinical courses and virus growth characteristics of the type 1 strains indicates that further virologic differentiation of these strains would be useful.
Author Affiliations
From the Institut für Virologie, Zentrum für Hygiene der Universität (Dr Neumann-Haefelin and Mr Wochnik), and the Universitäts-Augenklinik (Dr Sundmacher and Ms Bablok), Freiburg, West Germany.
Footnotes
Accepted for publication April 27, 1977.
Reprint requests to Institut für Virologie, Zentrum für Hygiene, Postfach 820, Hermann Herderstrasse 11, Freiburg, West Germany (Dr Neumann-Haefelin).
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