Noninvasive copper measurement in chalcosis: comparison with electroretinography and ophthalmoscopy

R. Gorodetsky, A. Weinreb, R. Zeimer and M. Belkin

The developement of chalcosis bulbi in rabbits' eyes is investigated by ophthalmoscopy, electroretinography, and diagnostic x-ray spectrometry (DXS), a new method for in vivo analysis and quantitation of metals. The DXS is shown to provide an effective method for the early detection of intraocular foreign bodies (IOFB) dissolution. The ophthalmoscopic changes observed in chalcosis are discussed in relation to dissolution of IOFB and electroretinographic findings.