The conjunctival sickling sign, hemoglobin S, and irreversibly sickled erythrocytes

doi:10.1001/archopht.95.5.808

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Vol. 95 No. 5, May 1977

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The conjunctival sickling sign, hemoglobin S, and irreversibly sickled erythrocytes

K. C. Nagpal, G. K. Asdourian, M. H. Goldbaum, M. Raichand and M. F. Goldberg

Sixty-five patients with hemoglobins AS, SC, and SS were investigated in a masked fashion. We observed a statistically significant positive correlation between the severity of conjunctival sickling signs and the counts of irreversibly sickled cells in each hemoglobinopathy group. We also observed a statistically significant positive correlation between the severity of the conjunctival vasculopathy and the percentage of sickle hemoglobin in the total group of patients with hemoglobins AS, SC, and SS.

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