Macular lesions associated with retinitis pigmentosa

G. A. Fishman, M. Fishman and J. Maggiano

Of 31 patients with retinitis pigmentosa, 18 (58%) had lesions of the retinal pigmentary epithelium within the maculae of both eyes. Six of the 31 patients (19%) showed macular cysts or holes (five bilateral, one unilateral) without angiographic evidence of leakage from perifoveal capillaries, while seven patients (23%) had macular cysts in both eyes associated with cystoid macular edema evident by fluorescein angiography. We believe that the macular cysts or holes were caused by changes at the vitreoretinal interface, eg, vitreous traction and preretinal membranes. Other pathologic sequences may also be responsible, such as an intrinsic increase in the permeability of retinal capillaries.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The prevalence of cystoid macular oedema in retinitis pigmentosa patients determined by optical coherence tomography
Hajali et al.
Br. J. Ophthalmol. 2008;92:1065-1068.
ABSTRACT | FULL TEXT  

ABCA4 mutations and discordant ABCA4 alleles in patients and siblings with bull's-eye maculopathy
Michaelides et al.
Br. J. Ophthalmol. 2007;91:1650-1655.
ABSTRACT | FULL TEXT  

High-Resolution Imaging with Adaptive Optics in Patients with Inherited Retinal Degeneration
Duncan et al.
IOVS 2007;48:3283-3291.
ABSTRACT | FULL TEXT  

Continued use of dorzolamide for the treatment of cystoid macular oedema in patients with retinitis pigmentosa
Fishman and Apushkin
Br. J. Ophthalmol. 2007;91:743-745.
ABSTRACT | FULL TEXT  

A detailed study of the phenotype of an autosomal dominant cone-rod dystrophy (CORD7) associated with mutation in the gene for RIM1
Michaelides et al.
Br. J. Ophthalmol. 2005;89:198-206.
ABSTRACT | FULL TEXT  

An Autosomal Dominant Bull's-Eye Macular Dystrophy (MCDR2) that Maps to the Short Arm of Chromosome 4
Michaelides et al.
IOVS 2003;44:1657-1662.
ABSTRACT | FULL TEXT  

Clinical Variations in Assessment of Bull's-eye Maculopathy
Kurz-Levin et al.
Arch Ophthalmol 2002;120:567-575.
ABSTRACT | FULL TEXT  

Disease Expression of RP1 Mutations Causing Autosomal Dominant Retinitis Pigmentosa
Jacobson et al.
IOVS 2000;41:1898-1908.
ABSTRACT | FULL TEXT  

A New 2-Base Pair Deletion in the RPGR Gene in a Black Family With X-Linked Retinitis Pigmentosa
Fishman et al.
Arch Ophthalmol 1998;116:213-218.
ABSTRACT | FULL TEXT