Timolol, dose response and duration of action
T. J. Zimmerman and H. E. Kaufman
Timolol maleate, a beta-adrenergic blocking agent, was used in a study of
20 adult patients with chronic open-angle glaucoma. This single-dose study
demonstrated a dose response for this drug using concentrations of 0.1%,
0.25%, 0.5%, and 1.0%. Timolol, 0.5%, appears to give the maximal ocular
hypotensive effect; however, each concentration of the drug produced an
ocular hypotensive effect for at least 24 hours. No local or systemic side
effects were discovered throughout the study. Timolol may be an effective,
innocuous, once-a-day, topical agent for the treatment of glaucoma.
