Aqueous humor ascorbate concentration and open-angle glaucoma
P. Lee, K. W. Lam and M. Lai
The mean value for aqueous concentration in 35 patients with open-angle
glaucoma was 22.4 +/- 12.9 mg/100 ml. The mean value for aqueous ascorbate
in four patients with uncomplicated senile cataract was 11.55 +/- 3.01
mg/100 ml. The results indicate that the majority of open-angle
glaucomatous eyes do not involve a deficiency of ascorbate, and suggest
that ascorbate has no therapeutic value in the management of primary
open-angle glaucoma. The magnitude of aqueous ascorbate variation among
glaucoma eyes is probably related to the factors that influence the patency
of trabecular meshwork, not the metabolic activity of the ciliary
processes.
