This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (2)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Priming Effect of Nonherpetic Uveitis

Jang O. Oh, MD, PhD

Arch Ophthalmol. 1977;95(11):2057-2061.

Abstract
• Systemic immunization of rabbits with herpes simplex virus (HSV) had two opposite effects on the outcome of subsequent efforts to produce primary HSV uveitis, the difference depending on whether or not the rabbits had had nonherpetic uveitis before the HSV challenge. In normal eyes, systemic immunization with HSV provided complete protection against the production of primary uveitis by an intraocular injection of HSV; but in eyes that had had a bout of experimentally induced nonherpetic uveitis before the challenge, the same systemic immunization was not protective. In these eyes, an immune-mediated uveal inflammation developed. Nonherpetic uveitis had apparently "primed" the eyes of the HSV-immune rabbits for subsequent immune-mediated HSV uveitis.

(Arch Ophthalmol 95:2057-2061, 1977)

Author Affiliations
From the Francis I. Proctor Foundation for Research in Ophthalmology, University of California, San Francisco.

Footnotes
Accepted for publication March 11, 1977.

Read before the annual meeting of the Ocular Microbiology and Immunology Group, Las Vegas, Oct 6, 1976.

Reprint requests to Francis I. Proctor Foundation, 315 Medical Sciences, University of California, San Francisco, CA 94143 (Dr Oh).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?