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Cecil V. Crabb, MD

Arch Ophthalmol. 1977;95(10):1866-1870.

Abstract
• Subconjunctival dibutyryl 3',5' cyclic adenosine monophosphoric acid (DBcAMP) produced a statistically significant reduction of ulceration in the alkaliburned rabbit cornea. No effect on epithelial cell growth was observed. DBcAMP also caused a statistically significant acceleration of corneal neovascularization in the first two weeks postburn. Medroxyprogesterone acetate also affected the development of corneal ulcers postalkali burn, but in a less well-defined manner. Dinoprost and indomethacin did not seem to influence this lesion. Cyclic adenosine monophosphoric acid may therefore possess a potential for use in the alkali-burned human eye.

(Arch Ophthalmol 95:1866-1870, 1977)

Author Affiliations
From the Department of Ophthalmology, University of North Carolina, School of Medicine, Chapel Hill. Dr Crabb is now in private practice in Winston-Salem, NC.

Footnotes
Accepted for publication Feb 23, 1977.

Read before the annual spring meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Fla, April 1977.

Reprint requests to Vinyard Garden Apartments, 141-10 Dalewood Dr, Winston-Salem, NC 27104 (Dr Crabb).

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