Endocrine influences on ulceration and regeneration in the alkali-burned cornea
C. V. Crabb
Subconjunctival dibutyryl 3',5' cyclic adenosine monophosphoric acid
(DBcAMP) produced a statistically significant reduction of ulceration in
the alkaliburned rabbit cornea. No effect on epithelial cell growth was
observed. DBcAMP also caused a statistically significant acceleration of
corneal neovascularization in the first two weeks postburn.
Medroxyprogesterone acetate also affected the development of corneal
ulcers postalkali burn, but in a less well-defined manner. Dinoprost and
indomethacin did not seem to influence this lesion. Cyclic adenosine
monophosphoric acid may therefore possess a potential for use in the
alkali-burned human eye.