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Use of Dexamethasone to Suppress Inflammation

A. Ralph Rosenthal, MD; COL Budd Appleton, MC, USA; Roger Zimmerman; Jerry L. Hopkins

Arch Ophthalmol. 1976;94(9):1571-1576.

Abstract
• In an attempt to prevent the intense inflammatory response to intravitreal copper foreign bodies in the rabbit eye, varying dosages of dexamethasone sodium phosphate were administered daily via the subconjunctival route. The steroid appeared to behave systemically and had similar effects in both the injected and the noninjected eyes. Its effect was similar also regardless of the concentration of copper within the foreign body. Nine days of dexamethasone therapy prevented a substantial number of copper foreign bodies from becoming totally encapsulated during that time. Furthermore, a delay in the onset of the inflammatory response to the foreign body was noted. In a few instances, inflammation was completely suppressed during the entire course of therapy.

Author Affiliations
From the Division of Surgery, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, DC, and the Division of Ophthalmology, Stanford University Medical Center, Stanford, Calif.

Footnotes
Accepted for publication March 29, 1976.

Reprint requests to Division of Ophthalmology, A-227, Stanford University Medical Center, Stanford, CA 94305 (Dr Rosenthal).

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