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A Clinicopathologic Study

Narsing A. Rao, MD; Mark O. M. Tso, MD; A. Ralph Rosenthal, MD

Arch Ophthalmol. 1976;94(8):1379-1384.

Abstract
• A clinicopathologic study of eight human eyes containing intraocular copper foreign bodies was undertaken. These foreign bodies, which had been retained in the eyes from three weeks to 22 years, were analyzed by atomic-absorption spectrophotometry and x-ray diffraction to determine their chemical composition. Copper deposits in Descemet membrane, vitreous, internal limiting membrane of the retina, and fibrous capsule around the foreign bodies could be demonstrated by rhodanine, rubeanic acid, and alizarin blue stains and were correlated with clinical findings and pathologic changes. Eyes with foreign bodies containing more than 85% copper tended to show more disseminated copper deposits. Eyes with alloy containing less than 85% copper showed more localized deposits of copper. Retinal structures were well preserved, even in an eye with an intraocular copper foreign body that had been retained for 22 years.

Author Affiliations
From the Registry of Ophthalmic Pathology, Armed Forces Institute of Pathology (Drs Rao and Tso); the Department of Ophthalmology, The Georgetown University Medical Center, Washington, DC (Dr Rao); and the Stanford University Medical Center, Stanford, Calif (Dr Rosenthal).

Footnotes
Accepted for publication Jan 26, 1976.

The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.

Reprint requests to Armed Forces Institute of Pathology, Washington, DC 20306 (Dr Tso).

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