This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (12)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Edward Cotlier, MD; Mark Baskin, MD; Joo Ok Kim, MD; Karen Lueck

Arch Ophthalmol. 1976;94(7):1159-1162.

Abstract
• In aqueous humor from rabbits with uveitis or after anterior chamber paracentesis, the levels of lysophosphatidyl choline (LPC) were 10.2µg/ml and 14.7µg/ml, respectively. These LPC levels induce early cataractous changes in the rabbit lens in culture. Analysis of the fatty acid composition of LPC showed that saturated fatty acids were more predominant in secondary aqueous humor than in primary aqueous humor. In vitro, natural LPC induced more pronounced gains in sodium ions and water by the lens than similar concentrations of synthetic L--lysopalmitoyl phosphatidyl choline. In contrast to prostaglandin E, the levels of LPC in aqueous humor of rabbits with uveitis are cataractogenic. Thus, LPC or its precursors, rather than prostaglandins, are involved in the production of cataracts in uveitis.

Author Affiliations
From the Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, Chicago.

Footnotes
Accepted for publication Dec 29, 1975.

Reprint requests to University of Illinois Eye and Ear Infirmary, 1855 W Taylor St, Chicago, IL 60612.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?