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II. Pathogenesis

Evangelos S. Gragoudas, MD; Suresh R. Chandra, MD; Ephraim Friedman, MD; Michael L. Klein, MD; Michael Van Buskirk, MD

Arch Ophthalmol. 1976;94(5):755-757.

Abstract
• Of 84 patients with unilateral disciform macular degeneration, 36 were followed up for one to four years (average, 22 months). The fellow eye in 13 cases developed disciform lesions during that follow-up period. A significantly greater number of drusen were found in the fellow eyes of patients with unilateral disciform macular degeneration than in the eyes of a comparable control group of patients (P<.001). Furthermore, the eyes with unilateral disciform macular degeneration that developed disciform lesions in the other eye were characterized as a group by a significantly larger number of drusen than those that did not. We postulate that drusen are precursors of disciform macular degeneration in fellow eyes and are probably manifestations of the same exudative process.

Author Affiliations
From the Department of Ophthalmology, Boston University School of Medicine. Dr Friedman is now at the Albert Einstein College of Medicine, Bronx, NY.

Footnotes
Accepted for publication Feb 14, 1974.

Reprint requests to Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461 (Dr Friedman).

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