This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Clinicopathologic Correlation of Two Cases With Neovascularization Beneath the Retinal Pigment Epithelium

Mary L. Small, MD; William R. Green, MD; John J. Alpar, MD; Richard E. Drewry, Jr, MD

Arch Ophthalmol. 1976;94(4):601-607.

Abstract
• The histopathologic findings in two cases of senile macular degeneration were correlated with the premortem clinical studies, from the onset in both cases and through the disciform stage in one case. In case 2, the postmortem eyes were obtained only one month after ophthalmoscopic, fluorescein angiographic, and fundus photographic studies were performed, all on the same day. Our report not only adds to the few clinicopathologic correlations of the lesions in senile macular degeneration reported in the literature, but also presents the first reconstruction to scale of subretinal pigment epithelial (sub-RPE) neovascularization.

Our results confirm the diagnosis of sub-RPE neovascularization and serous detachment of the retinal pigment epithelium. Drusen were correlated as to number and general location but not individually. Serous detachment of the neurosensory retina was found histopathologically but not clinically.

Author Affiliations
From the Eye Pathology Laboratory, Wilmer Institute, and the Department of Pathology, Johns Hopkins Medical Institutions, Baltimore. Presented in part at the Wilmer Residents' Association meeting, April 19, 1974.

Footnotes
Submitted for publication Oct 21, 1974.

Reprint requests to Eye Pathology Laboratory, Johns Hopkins Hospital, 601 N Broadway, Baltimore, MD 21205 (Dr Small).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Clinicopathologic Correlation of Successfully Treated Choroidal Neovascularization Lying Within the Notch of a Large Serous Retinal Pigment Epithelial Detachment
Lauer et al.
Arch Ophthalmol 2004;122:1383-1390.
FULL TEXT  

Age-Related Retinal Pigment Epithelium and Bruch's Membrane Degeneration in Senescence-Accelerated Mouse
Majji et al.
IOVS 2000;41:3936-3942.
ABSTRACT | FULL TEXT  

Clinicopathological correlation in exudative age related macular degeneration: histological differentiation between classic and occult choroidal neovascularisation
Lafaut et al.
Br J Ophthalmol 2000;84:239-243.
ABSTRACT | FULL TEXT  

Decreased choriocapillaris perfusion following surgical excision of choroidal neovascular membranes in age-related macular degeneration
Nasir et al.
Br J Ophthalmol 1997;81:481-489.
ABSTRACT | FULL TEXT  

Clinicopathologic Correlation of Occult Choroidal Neovascularization in Age-Related Macular Degeneration
Bressler et al.
Arch Ophthalmol 1992;110:827-832.
ABSTRACT  

Subfoveal Neovascular Lesions in Age-Related Macular Degeneration: Guidelines for Evaluation and Treatment in the Macular Photocoagulation Study
Macular Photocoagulation Study Group
Arch Ophthalmol 1991;109:1242-1257.
ABSTRACT  

Cellular Mechanisms of Resolution of Drusen After Laser Coagulation: An Experimental Study
Duvall and Tso
Arch Ophthalmol 1985;103:694-703.
ABSTRACT  

A Histopathologic Study of Best's Macular Dystrophy
Frangieh et al.
Arch Ophthalmol 1982;100:1115-1121.
ABSTRACT  

Presumed Ocular Histoplasmosis Syndrome: A Clinicopathologic Correlation of a Treated Case
Sheffer et al.
Arch Ophthalmol 1980;98:335-340.
ABSTRACT