Ocular toxoplasmosis in an adult receiving long-term corticosteroid therapy
D. H. Nicholson and E. B. Wolchok
Sudden death of a 58-year-old woman who developed ocular toxoplasmosis
while receiving long-term systemic corticosteroid therapy permitted
correlation of early histopathologic lesions with their clinical
counterpart recorded on fundus photographs. A wide-spread, paravascular,
whitish, retinal opacification dominated the initial clinical picture.
These lesions were represented histologically by focal zones of inner
retinal necrosis located adjacent to arteries and veins. No associated
inflammatory cell infiltrate was present, and numerous viable free
Toxoplasma organisms were consistently present at the interface between
necrotic and healthy retina. Electron microscopy of formaldehyde-fixed
tissue provided a useful technique for confirming the identity of the
infecting organism in the absence of serologic or culture data.
Effects of Sulfamethoxazole on Murine Ocular Toxoplasmosis in Interferon-{gamma} Knockout Mice
Norose et al.
IOVS 2006;47:265-271.
ABSTRACT
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Infliximab and Reactivation of Cerebral Toxoplasmosis
Young et al.
NEJM 2005;353:1530-1531.
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IFN-{gamma}-Regulated Toxoplasma gondii Distribution and Load in the Murine Eye
Norose et al.
IOVS 2003;44:4375-4381.
ABSTRACT
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Severe bilateral necrotising retinitis caused by Toxoplasma gondii in a patient with systemic lupus erythematosus and diabetes mellitus
Yamamoto et al.
Br. J. Ophthalmol. 2003;87:651-652.
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Toxoplasma gondii Infection Induces Gene Expression and Secretion of Interleukin 1 (IL-1), IL-6, Granulocyte-Macrophage Colony-Stimulating Factor, and Intercellular Adhesion Molecule 1 by Human Retinal Pigment Epithelial Cells
Nagineni et al.
Infect. Immun. 2000;68:407-410.
ABSTRACT
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Sense and nonsense of corticosteroid administration in the treatment of ocular toxoplasmosis
BOSCH-DRIESSEN and ROTHOVA
Br. J. Ophthalmol. 1998;82:858-860.
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