This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (16)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Allan Kupferman, PhD; Howard M. Leibowitz, MD

Arch Ophthalmol. 1976;94(11):1981-1984.

Abstract
• We report an experimental model that allows objective quantitation of bacterial keratitis. The model permits direct measurement of the number of viable organisms in the cornea after varying periods of in vivo growth. The size of the inoculum used to produce the corneal infection is critical, and the experimental organism must be standardized for its growth characteristics in the cornea. The end point is an objective one, productive of numerical data that can be subjected to statistical analysis. The findings are highly reproducible and the system is sufficiently sensitive to indicate the ability of a topically administered antibiotic to reduce the number of viable organisms in the cornea of an outbred rabbit population.

Author Affiliations
From the Department of Ophthalmology, the Massachusetts Lions Eye Research Laboratory (Drs Kupferman and Leibowitz), and the Department of Pharmacology (Dr Kupferman), Boston University School of Medicine.

Footnotes
Accepted for publication July 2, 1976.

Reprint requests to Boston University School of Medicine, 80 E Concord St, Boston, MA 02118 (Dr Leibowitz).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The Collagen-Binding Adhesin Is a Virulence Factor in Staphylococcus aureus Keratitis
Rhem et al.
Infect. Immun. 2000;68:3776-3779.
ABSTRACT | FULL TEXT  

Treatment of Experimental Pseudomonas Corneal Ulcers With Enoxacin, a Quinolone Antibiotic
Sugar et al.
Arch Ophthalmol 1986;104:1230-1232.
ABSTRACT  

A Rat Model of Bacterial Keratitis: Effect of Antibiotics and Corticosteroid
Badenoch et al.
Arch Ophthalmol 1985;103:718-722.
ABSTRACT  

Route of Antibiotic Administration in Bacterial Keratitis
Leibowitz et al.
Arch Ophthalmol 1981;99:1420-1423.
ABSTRACT  

Topically Administered Corticosteroids: Effect on Antibiotic-Treated Bacterial Keratitis
Leibowitz and Kupferman
Arch Ophthalmol 1980;98:1287-1290.
ABSTRACT  

Topical Antibiotic Therapy of Pseudomonas aeruginosa Keratitis
Kupferman and Leibowitz
Arch Ophthalmol 1979;97:1699-1702.
ABSTRACT  

Staphylococcal Keratitis: Experimental Model in Guinea Pigs
Davis et al.
Arch Ophthalmol 1978;96:2114-2116.
ABSTRACT  

Topical Antibiotic Therapy of Staphylococcal Keratitis
Kupferman and Leibowitz
Arch Ophthalmol 1977;95:1634-1637.
ABSTRACT  

Antibiotic Therapy of Experimental Pseudomonas Keratitis in Guinea Pigs
Davis et al.
Arch Ophthalmol 1977;95:1638-1643.
ABSTRACT