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Treatment of Vaccinial Keratitis With Trifluorothymidine
Robert A. Hyndiuk, MD;
Sam Seideman, MD;
Joel M. Leibsohn, MD
Arch Ophthalmol. 1976;94(10):1785-1786.
Abstract
• The efficacy of trifluorothymidine was compared with idoxuridine on a blind basis by noting the effect of topical administration of the drugs on the severity of vaccinial keratitis induced in rabbits. Trifluorothymidine was found to be substantially more effective, and was well tolerated. In addition, positive viral cultures after the treatment period were substantially reduced in the trifluorothymidine groups when compared with the idoxuridine or control groups.
Author Affiliations
From the Cornea-External Disease Unit, Department of Ophthalmology, Medical College of Wisconsin, Milwaukee (Drs Hyndiuk and Seideman); and the Department of Ophthalmology, University of Iowa, Iowa City (Dr Leibsohn).
Footnotes
Accepted for publication May 21, 1976.
Reprint requests to Cornea-External Disease Unit, Milwaukee County Medical Complex, 8700 W Wisconsin Ave, Milwaukee, WI 53226 (Dr Hyndiuk).
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