This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (13)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Gholam A. Peyman, MD; Charles M. Vygantas, MD; Thomas O. Bennett, MD; Auste M. Vygantas, PhD; Stephen Brubaker, MD

Arch Ophthalmol. 1975;93(7):514-517.

Abstract
Vitreous replacement with air, pure octafluorocyclobutane (C₄F₈), and mixtures of 40% C₄F₈ and 60% air was done in owl monkeys to determine ocular toxicity and duration of gas within the vitreous compartment. Large volumes of gas mixture and pure C₄F₈ caused posterior subcapsular cataract formation. Pure C₄F₈ expands in the vitreous within 24 to 48 hours. A 1.0-ml mixture of 40% C₄F₈ and 60% air lasted 12.7 days and did not cause ocular changes. However, anterior chamber aqueous replacement with pure C₄F₈ or gas mixture resulted in cataract production.

Twenty-four and fourty-eight hours after injection of 0.1-ml pure C₄F₈ in the vitreous of experimental rabbits, presence of oxygen, nitrogen, and carbon dioxide was shown by gas chromatographic analysis. This finding supports the hypothesis of volume expansion secondary to diffusion of above-mentioned gases inside the C₄F₈ gas bubble.

Author Affiliations
From the Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, and the Department of Biochemistry, Northwestern Medical School, Chicago.

Footnotes
Submitted for publication April 13, 1974.

Reprint requests to 1855 W Taylor St, Chicago, IL 60612 (Dr. Peyman).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The Ocular Effects of Gases When Injected Into the Anterior Chamber of Rabbit Eyes
Lee et al.
Arch Ophthalmol 1991;109:571-575.
ABSTRACT  

Delayed Suprachoroidal Hemorrhage Following Filtration Surgery
Kaplan et al.
Arch Ophthalmol 1988;106:585-585.
ABSTRACT  

Intraocular Pressure Assessment in Gas-Filled Eyes Following Vitrectomy
Poliner and Schoch
Arch Ophthalmol 1987;105:200-202.
ABSTRACT  

The Effect of Perfluoropropane on the Cornea in Rabbits and Cats
Foulks et al.
Arch Ophthalmol 1987;105:256-259.
ABSTRACT  

Intraocular Sulfur Hexafluoride and Octofluorocyclobutane: Effects on Intraocular Pressure and Vitreous Volume
Killey et al.
Arch Ophthalmol 1978;96:511-515.
ABSTRACT