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Samuel Packer, MD; Carol Redvanly; Richard M. Lambrecht, PhD; Alfred P. Wolf, PhD; Harold L. Atkins, MD

Arch Ophthalmol. 1975;93(7):504-508.

Abstract
Using the Greene melanoma In the hamster (Syrian Golden), the radlopharmaceutical, ¹²³I-4(3-dimethylaminopropylamino)-7-iodoquinoline, was tested for Its ability to localize melanoma. This quinoline analog has been described for use in the detection of melanoma, but this Is the first report, to our knowledge, of its being used with an ¹²³I label.

Hamsters with either skin or eye melanomas were studied. Both melanomas could be seen with a gamma camera at three hours after injection. In vitro analysis confirmed the tumor specificity. Thus, it appears that this preclinical trial of a new radiopharmaceutical justifies clinical testing to determine its value in the localization of melanomas of the eyes and skin of humans.

Author Affiliations
From the Medical Research Center (Drs. Packer and Atkins), the Department of Chemistry (Ms. Redvanly and Drs. Lambrecht and Wolf), Brookhaven National Laboratories, Upton, NY, and the Department of Surgery (Ophthalmology), the North Shore University Hospital (Dr. Packer), Manhasset, NY.

Footnotes
Submitted for publication Feb 6, 1974.

Read before the spring meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Fla, May 1973.

Reprint requests to North Shore University Hospital, 300 Community Dr, Manhasset, NY 11030 (Dr. Packer).

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