Ocular anti-inflammatory effect of fenoprofen. Dose-response study

L. S. Harris and Y. Kahanowicz

An experimental rabbit uveitis model was used to establish a dose response range for topical administration of fenoprofen (dl-2(3-phenoxyphenyl) propionic acid. The 0.3% concentrate group was not distinguishable from the untreated group, and 3% concentrate proved highly irritating. Fenoprofen 1%, pH 6.4, proved most efficacious and had an effect comparable to dexamethasone phosphate 0.1%, seen in a previous study.