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II. Teratogenicities and Tissue Accumulation of Thimerosal

Antonio R. Gasset, MD; Motokazu Itoi, MD; Yasuo Ishii; Richard M. Ramer, PhD

Arch Ophthalmol. 1975;93(1):52-55.

Abstract
Under the conditions of this study, systemically or topically applied thimerosal was found to have no teratogenic effect even when given in concentrations approaching the 50% lethal dose of these compounds. A comparison of topical and subcutaneous administration of thimerosal to rabbits shows that a substantial concentration of mercury was present in blood and tissues of the treated animals and their offspring. Thimerosal was found to cross the blood-brain and placenta barriers.

Author Affiliations
From the Department of Ophthalmology, College of Medicine, University of Florida, Gainesville.

Footnotes
Submitted for publication May 25, 1973.

Reprint requests to Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, FL 32601 (Dr. Gasset).

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