Teratogenicities of ophthalmic drugs. II. Teratogenicities and tissue accumulation of thimerosal
A. R. Gasset, M. Itoi, Y. Ishii and R. M. Ramer
Under the conditions of this study, systemically or topically applied
thimerosal was found to have no teratogenic effect even when given in
concentrations approaching the 50% lethal dose of these compounds. A
comparison of topical and subcutaneous administration of thimerosal to
rabbits shows that a substantial concentration of mercury was present in
blood and tissues of the treated animals and their offspring. Thimerosal
was found to cross the blood-brain and placenta barriers.
